Plasma diazepam levels after single dose oral and intramuscular administration
نویسندگان
چکیده
منابع مشابه
Plasma and cerebrospinal fluid pharmacokinetic parameters after single-dose administration of intravenous, oral, or rectal acetaminophen.
BACKGROUND This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR) formulations of acetaminophen. METHODS Healthy male subjects (N = 6) were randomized to receive a single dose of IV (OFIRMEV(®) ; Cadence) 1,000 mg (15 minute infusion), PO (2 Tylenol(®) 500 mg caplets; McNeil Consumer Healthcare), or PR acetaminop...
متن کاملBlood lidocaine levels and kinetics following high-dose intramuscular administration.
a high dose (6 mg/kg) of lidocaine, and blood lidocaine levels were measured over a 4-hour study period. Intradeltoid injection produced higher blood lidocaine levels and more rapid development of peak blood levels than did intragluteal injection. Administration of high-dose lidocaine (average dose 450 mg) into the deltoid muscle produced the ideal combination of rapid peak blood levels (6.5 gg...
متن کاملPlasma concentrations of enrofloxacin after single-dose oral administration in loggerhead sea turtles (Caretta caretta).
Plasma concentrations and pharmacokinetics of enrofloxacin were determined in 12 loggerhead sea turtles (Caretta caretta) after oral administration. Six turtles in group 1 and group 2 received enrofloxacin at 10 mg/kg and 20 mg/kg of body weight, respectively. Blood was collected from the cervical sinus before administration and at timed intervals up to 168 hr following administration. Plasma c...
متن کاملRapid, precise, turbidometric assay for low levels of ampicillin in serum after single-dose oral administration.
A turbidometric assay is described for the quantitative measurement of ampicillin in serum. Standard curves prepared with known concentrations of ampicillin in serum exhibited acceptable linearity over a concentration range of approximately 0.2 to 1.8 mug/ml. Data are presented to show the excellent precision of the assay and the application of the assay to clinical studies. The advantages of t...
متن کاملPlasma androgens after a single oral dose of testosterone undecanoate.
Total plasma androgens (PA) were measured in 9 hypogonadal males aged between 13 and 21 1/2 years after a single oral dose of testosterone undecanoate (TU). With the exception of one patient, all showed a rise in PA with peak values between 7.7 and 38.0 nmol/l at 2 to 7 hours. A further patient aged 15.7 years who was given an 80-mg dose had a peak PA level of 71.2 nmol/l. In all patients PA re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anaesthesia
سال: 1975
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1975.tb00828.x